Faino et al. (2025) CHP2 modifies chronic Pseudomonas aeruginosa airway infection risk in cystic fibrosis
Taking advantage of longitudinal clinical data for nearly 5,000 people with Cystic Fibrosis (CF), we performed a genome-wide association study for time to chronic Pa infection. We identified a common noncoding variant near the gene CHP2 significantly associated with a nearly 3-year delay in the onset of chronic Pa for alternate allele homozygotes. This variant is associated with the expression of CHP2 in the lung, which itself is associated with lung function among people with CF. Contributing consortia: Cystic Fibrosis Genome Project.